Short fingers and wide space between the big toe and second toe in a newborn suggest which condition?

The presence of short fingers and a wide space between the big toe and the second toe in a newborn is indicative of Down syndrome, also known as Trisomy 21. This genetic condition is characterized by a set of physical and developmental features, including specific dysmorphic traits such as a single transverse palmar crease, a flattened facial profile, and a gap between the first and second toes, commonly referred to as a sandal gap.

In Down syndrome, the combination of these features arises from the presence of an extra copy of chromosome 21, leading to the characteristic patterns of growth and development seen in affected individuals. Recognition of these traits is important for early diagnosis and intervention to ensure that appropriate support is provided to the infant and family. Understanding the typical physical manifestations of Down syndrome can aid healthcare professionals in making informed assessments and recommendations for ongoing care.