What is the name of the progressive degenerative neurological disease characterized by collections of abnormal neurons and glia?

The condition characterized by collections of abnormal neurons and glia, leading to a progressive degenerative neurological disease, is commonly recognized as Tuberous sclerosis. This genetic disorder results in the formation of benign tumors, known as hamartomas, in various organs including the brain. These growths can disrupt normal brain function and development, contributing to a range of neurological symptoms, and they are particularly significant due to the impact on neuronal structure.

Tuberous sclerosis is unique in its presentation and the pathological findings associated with the disease involve the proliferation of both neurons and glial cells. This is a defining feature that distinguishes it from other conditions like multiple sclerosis, which is primarily characterized by demyelination rather than abnormal collections of neurons and glia, or Parkinson's disease, which is noted for the degeneration of dopamine-producing neurons in the substantia nigra. Alzheimer's disease, on the other hand, is marked by amyloid plaques and tau tangles, further differentiating it from the processes seen in Tuberous sclerosis.