What syndrome can present with both lower limb defects and abdominal wall issues?

Eagle-Barrett syndrome, also known as prune belly syndrome, is characterized by a triad of findings: incomplete development of the abdominal muscles, urinary tract anomalies, and cryptorchidism. It is particularly associated with lower limb defects and abdominal wall issues, making it the most relevant choice in this context. The abdominal wall issues arise from the lack of muscle development, which can lead to a prominent abdomen and other complications. Furthermore, the urinary tract anomalies can sometimes be part of a spectrum that includes limb morphology variations, hence linking lower limb defects with the syndrome.

In contrast, Turner syndrome primarily involves chromosomal abnormalities leading to features such as short stature and congenital heart defects but does not specifically present with lower limb defects or abdominal wall abnormalities. Down syndrome is known for its characteristic facial features, developmental delays, and associated congenital conditions, but it also does not typically present with both lower limb and abdominal wall issues in the way that Eagle-Barrett syndrome does. Wilms tumor is a kidney cancer in children and is unrelated to lower limb defects or abdominal wall abnormalities, focusing instead on renal pathology.

Thus, the selection of Eagle-Barrett syndrome as the correct answer is based on its distinctive association with the mentioned lower limb and abdominal wall issues.