Which abnormal condition often occurs alongside genetic defects such as Down syndrome?

Syndactyly is an abnormal condition characterized by the fusion of two or more fingers or toes. This particular condition can often occur alongside various genetic defects, including Down syndrome, as these congenital anomalies frequently present with associated physical traits. In the context of Down syndrome, individuals may have certain developmental and anatomical variations, including syndactyly, as part of the spectrum of possible syndromic features.

Syndactyly is linked to abnormal limb development during the embryonic phase, which can be influenced by genetic factors. Therefore, its association with genetic conditions like Down syndrome serves as an example of how certain abnormalities may co-occur due to shared genetic pathways.

In contrast, while thalassemia is a genetic blood disorder, polydactyly refers to the presence of extra fingers or toes, and hypoglycemia reflects a metabolic condition rather than a structural defect, making their relevance to Down syndrome less direct.