Which assessment finding indicates a need for further investigation in an infant with potential osteogenesis imperfecta?

Frequent fractures indicate a need for further investigation in an infant with potential osteogenesis imperfecta (OI) because this condition is characterized by a tendency to fracture easily due to bone fragility resulting from a defect in collagen formation. While other findings, such as blue sclera, muscle weakness, and difficulty gaining weight, might be associated with a variety of other conditions or complications, frequent fractures are a hallmark sign of OI.

In cases of OI, the clinical severity often correlates with the frequency and severity of fractures. Infants with OI may display multiple fractures, including those occurring with minimal or no trauma, which can be alarming and warrant a thorough evaluation and investigation. Identifying the pattern and causes of these fractures becomes critical in establishing the diagnosis and determining appropriate care and management strategies for the infant.

Thus, frequent fractures are a compelling sign of the underlying pathology associated with osteogenesis imperfecta and necessitate a more in-depth assessment to confirm the diagnosis and implement a suitable plan of care.